Global Cause
Clinical Trials
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s Sponsored
Patient-derived organoids are de-risking clinical drug development
Biotechnology company merges with a leading global life science and technology company to enhance its offering of patient-derived organoid services for clinical drug development. Drug development is a long, costly and high-risk process, often taking upwards of 10–15 years, and typically costing over £1 billion for each new therapy. Drug candidate attrition rates Despite significant...
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Tackling common disease burden through clinical trial innovation
Clinical trials are the difference between treating with hope and treating with knowledge. With an explosion in therapeutic opportunities — personalised cancer vaccines, gene-editing for lifelong cholesterol reduction, annual injections to lower blood pressure and novel therapies to prevent the onset of dementia — clinical trials are essential to establish whether what looks good in...
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Good Trials Prism: collaboration to bolster clinical trials in LMICs
In August 2023, the Good Clinical Trials Collaborative (the Collaborative) and four major research networks unveiled a strategic partnership to bolster clinical trials research in low and middle-income countries (LMICs). With ADVANcing Clinical Evidence in Infectious Diseases, Africa Health Research Institute, Oxford University Clinical Research Unit in Vietnam and The Global Health Network — the Wellcome-funded...
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Breaking down the barriers of academic multinational trials
In Europe, almost half of clinical trials are carried out by academics in University Hospitals and other public organisations. While most industry-sponsored trials are multinational, the vast majority of investigator-initiated trials are conducted in a single country. Even though some academics develop solutions with novel treatments, diagnostics or vaccines, their work often focuses on comparative...
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Ways to strengthen the clinical research ecosystem in resource-limited settings
Encouraging clinical research in low-income settings is essential to tap into opportunities that can make a difference in patients’ lives. Creating a sustainable clinical research ecosystem requires open and close collaboration. The pharmaceutical industry is a crucial contributor to this ecosystem in designing, initiating and running global clinical trials according to the highest regulatory and...
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s Sponsored
Streamlining clinical trials: overcoming the diagnostics challenge
As clinical trials become decentralised/hybrid with people increasingly taking part from home, a major challenge remains collecting samples for diagnostic testing. Monitoring participants’ vital signs via wearable technology is becoming commonplace in clinical trials. Yet, the collection and analysis of diagnostics remains a logistical challenge. On-site tests require participants to visit a trial site —...
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s Sponsored
Delivering better clinical trial datasets with the cloud
The cloud holds the potential to help hospitals, researchers and doctors to deliver clinical trials that scale and improve patient experience. The cloud has the potential to help life sciences organisations scale, improve the clinical trial process and offer a more patient-centric experience. Modernised clinical trials allow providers to focus on their role in discovering...
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Increasing trust in real world data through new framework
When new treatments are brought to the market, they go through multiple assessments to ensure that they are safe, effective and good value for money. However, questions still remain. The questions that need answering during this journey are many and diverse. It is therefore no surprise that no one study design is ideal for answering...
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How smarter trials can tackle the rising health burden
In recent decades, while global life expectancy has improved, the burden of common and other life-threatening conditions on global populations continues to rise. Despite this trend, the development of new treatments for major health conditions such as heart and lung disease, arthritis, depression and dementia has dwindled, with focus instead on rare conditions where returns...
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s Sponsored
Keeping the new clinical trial landscape safe
With the transition to hybrid and decentralised clinical trials, the need to ensure they continue to meet stringent regulatory requirements remains paramount. Yet the shift away from the traditional trial format offers a number of benefits, such as increasing diversity in participating patient groups. Economic benefits Dr Rashmi Narayana suggests the digital elements of decentralised...