Global Cause
In this issue
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Why polymerase chain reaction diagnostics are key to fighting AMR
In the fight against antimicrobial resistance (AMR), accurate polymerase chain reaction testing is key to safeguarding antibiotics and improving patient care. When it comes to treating infectious diseases, the target is constantly shifting as bacteria mutate. This might not be an issue if antibiotics were being developed to keep pace, but the fact is: they’re...
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History shows value of partnership to tackle health challenges
An innovative model of partnership has brokered global health breakthroughs for 40 years. Now partners are eyeing the future. In 1980, the world was declared free of smallpox- the only human disease ever to be eradicated, marking a historic milestone and catalysing subsequent global health achievements. Eradicating smallpox was like landing on the moon; it’s...
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Why ‘doing just enough’ to combat malaria is a deadly strategy
We cannot afford to stand still in our fight against malaria, a treatable disease causing preventable deaths. There needs to be a cosmic shift in how it’s tackled. Malaria is an ever-evolving disease. If we continue to do ‘just enough’ to combat it, any progress we make simply ebbs away — and, consequently, many more...
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Mairo’s vital role in defeating severe malaria as a children’s health nurse
Mairo is the matron of an emergency paediatric unit at a hospital in Nigeria. She is part of a team caring for seriously ill children experiencing severe malaria. Caregivers anxiously wait by bedsides, hoping treatments will work and their loved ones make a full recovery. Severe malaria is a medical emergency resulting from delayed treatment...
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Redefining TB treatment: the promise of shorter, simpler and universal regimens
Help halt the TB pandemic with shorter, simpler and more effective cures. Unlock the future of treatment with pan-TB regimens that can cure all forms of TB, including drug-resistant strains. While new drugs have emerged in recent years, successfully treating TB remains a complex challenge. Existing regimens require months of adherence, placing a heavy burden...
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AMR in LMICs: moving evidence into action
AMR poses a universal challenge across all sectors of One Health. Urgent action is vital to translate evidence into interventions, especially in low and middle-income countries where the burden is most severe. Patients in low and middle-income countries (LMICs) frequently encounter barriers to essential services, including long wait times, inadequate facilities and shortages of medical...
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Collaborative science: key aspect to successful vaccine development
When another pandemic strikes, new technologies and collaborative strategies will be crucial to helping the scientific community develop drugs and vaccines in the fastest way possible. It’s not a question of ‘if’ another global pandemic will strike, insists Luc Gagnon, PhD — but a question of ‘when.’ “It’s just a matter of time,” he says...
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Link between fatal disease noma and extreme poverty
Noma is a devastating disease linked to extreme poverty. Discover the WHO’s urgent call for awareness, funding and collaboration and how to make a difference. On 15 December 2023, the World Health Organization (WHO) announced that noma has been included in the list of neglected tropical diseases (NTDs). This recognition spurs hope in the small...
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Controlled human infection models: accelerating tropical disease solutions
Controlled human infection models can accelerate vaccine efficacy testing and treatment validation for malaria, dengue, tuberculosis and other tropical diseases. Tropical diseases, including malaria, dengue and tuberculosis impose a significant global health challenge, with millions of cases reported worldwide. Existing preventive treatments often fall short, necessitating the development of new vaccines and antimicrobial therapies. However,...
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Change needed to break the chain of tuberculosis
End tuberculosis in high-burden countries. Adapt and implement evidence-based interventions to stop the spread of this deadly, but curable, disease. The incidence of tuberculosis (TB) in countries with a high burden of this airborne disease is falling at a glacial pace. In 2022, 10.6 million people fell ill with TB and 1.3 million died —...