Global Cause
In this issue
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The world better be prepared for a silent pandemic!
Antibiotics have shaped the way we prevent and treat bacterial infections, however without quick interventions required in the field, we could be on the cusp of losing the battle to antimicrobial resistance (AMR), the silent pandemic. It all started in 1928 with Alexander Fleming and the discovery of penicillin. Antibiotics changed humanity more than any...
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New antibiotics alone are not the answer to AMR
AMR is a growing threat to global health. But, as well as developing new drugs, which bacteria may also grow resistant to, should we not be making better use of those we already have? Antimicrobial resistance (AMR) is one of the biggest threats facing the world today, but innovation alone – while a critical part...
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Europe’s medicine cabinet is running out of new antibiotics
But the UK and Sweden may have answers. They are tackling the antimicrobial crisis head on by taking a new approach that turns the current payment system for innovative drugs on its head. Antibiotics have been the best deal in healthcare for decades. However, the relatively low cost of drugs, coupled with growing resistance, and...
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Reasons to be optimistic about new antibiotic development
Two years ago, the outlook for viable antibiotics looked bleak. Now policymakers have realised the scope of the problem, while a number of new innovations are in the pipeline. Bacteria are clever, says Dr Christopher Burns, President and CEO of Pennsylvania-based pharma company, Venatorx Pharmaceuticals. You can put them under pressure with an antibiotic, but...
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Diagnostic tests are vital in the fight against antimicrobial resistance
The coronavirus pandemic has focussed the world’s attention on the role and importance of diagnostic testing. Diagnostic tests provide essential data to support treatment decisions; 70% of patient information comes from diagnostic tests. Many tests are done in hospital laboratories, but increasingly, technological improvements are enabling access to tests outside traditional settings. Keeping the focus...
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How to change the fight against AMR?
Novel interventions to stem the rising tide of AMR are urgently needed. SMEs are the innovation engine in this field. A multi-directional approach is critical to win the war against antimicrobial resistance (AMR). SMEs are developing interventions that tackle AMR in six different areas to meet patients’ requirements1. Diversifying the field of fight against AMR...
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Improving old antibiotics – does it make any sense?
It does make complete sense. Most of the antibiotics of the “golden age of antibiotic discovery” have now been replaced by their improved versions. This has happened to the archetypical betalactam, penicillin G. Now we use its fourth generation. The same is true of the first cephalosporin, cephalothin. Now we use its fifth generation. Similarly,...
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Rapid antimicrobial resistance detection for MDR infections
In the last decades, the problem of antimicrobial resistance (AMR) has reached critical proportions to induce global health authorities to regard AMR as a today’s “serious threat” worldwide. Targeting AMR has important clinical implications, not only related to diagnosis and management, but also prevention of infectious diseases, particularly those causing sepsis. Factors associated with death...
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World Antimicrobial Awareness Week (WAAW) – events calander
17th November 15.00 – 16.20: AMR: What has the scientific community learned with the World Federation of Science Journalists 18th November 10:00 – 12:00: Webinar: WAAW 2020 kickoff in Africa 14:30 – 17:20: Webinar: New developments and innovations to address AMR/Addressing the crisis in antimicrobials research and development 15:00-16:00: CDC: Twitter Storm 16:00 – 16:30:...
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Filling the innovation void to tackle AMR
A renewed and sustainable pipeline of effective antibiotics is vital to modern medicine. New thinking offers a patient-centric approach to antibiotic development to tackle resistance and improve health outcomes. Recent antibiotic drug approvals have largely been based on existing antibiotic classes, providing a stop gap, but not a long-term solution. “The most recent market launches...